어벤져스 멤버들과 타노스와의 대접전을 마친 뒤, 지난 5년 동안 사라졌던 사람들이 동시에 돌아왔다. 아이언맨이 떠난 채 한동안 지구를 구할 히어로가 공석인 상황을 수습할 히어로는 현재 스파이더맨 피터 파커뿐이다. 친구들과의 유럽 현장학습 도중 닉 퓨리의 부름을 받게 된 피터는 미스테리오라는 정체 모를 히어로와 힘을 합쳐 엘리멘탈이라는 괴생명체를 무찔러야 하는 상황에 처한다. 그런데 피터는 지구를 구하는 일보다 MJ에게 멋지게 고백할 계획이 우선인데...
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Tom Holland
Peter Parker / Spider-Man
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Samuel L. Jackson
Nick Fury
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Jake Gyllenhaal
Quentin Beck / Mysterio
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Marisa Tomei
May Parker
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Jon Favreau
Harold 'Happy' Hogan
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Zendaya
Michelle 'MJ' Jones
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Jacob Batalon
Ned Leeds
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Tony Revolori
Eugene 'Flash' Thompson
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Angourie Rice
Betty Brant
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Remy Hii
Brad Davis
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Martin Starr
Mr. Harrington
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J.B. Smoove
Mr. Dell
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Jorge Lendeborg Jr.
Jason Ionello
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Cobie Smulders
Maria Hill
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Numan Acar
Dimitri
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Zach Barack
Zach
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Zoha Rahman
Zoha
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Yasmin Mwanza
Yasmin
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Joshua Sinclair-Evans
Josh Spinelli
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Tyler Luke Cunningham
Tyler
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Toni Garrn
The Seamstress
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Peter Billingsley
William Ginter Riva
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Clare Dunne
Victoria
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Nicholas Gleaves
Guterman
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Claire Rushbrook
Janice
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J.K. Simmons
J. Jonah Jameson
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Jeroen van Koningsbrugge
Dutch Soccer Hooligan 1
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Michael de Roos
Dutch Soccer Hooligan 2
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Jan-Paul Buijs
Dutch Soccer Hooligan 3
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Sergio Pierattini
Venetian Glassblower
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Evelyn Mok
Queens Reporter
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Giada Benedetti
Italian Customs Office
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Lukáš Bech
Helpful Dutch Man
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Alessandro Giuggioli
Italian Street Vendor
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Pat Kiernan
Himself
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Shari Abdul
High School Reporter (uncredited)
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Ria Fend
Tourist in Venice (uncredited)
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Brendan Murphy
Police Officer (uncredited)
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Vincent Angel
Midtown High Student (uncredited)
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Peter Arpesella
Airplane Pilot (uncredited)
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Lasco Atkins
Salvation Army guest (uncredited)
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Joseph Long
Mob Boss (uncredited)
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Blair Barnette
Queens Reporter (uncredited)
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Tuwaine Barrett
Officer Bristow (extended cut)
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Pierre Bergman
Venice Fish Seller (uncredited)
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Sharon Blynn
Soren (uncredited)
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Jeff Bridges
Obadiah Stane (archive footage) (uncredited)
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Gianni Calchetti
Venetian Fish Stall Owner (uncredited)
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Cailan Robinson
Victoria's Crew (uncredited)
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Hélène Cardona
Austrian Backpacker (uncredited)
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Dian Cathal
American Reporter (uncredited)
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Emmanuel Rodriguez
Airport Traveler (uncredited)
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Daphne Cheung
Passport Clerk (uncredited)
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Al Clark
Cowboy Plane Passenger (uncredited)
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Kimberly Collison
Charity Event Mom (uncredited)
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Melissa Beth Miller
Tourist (uncredited)
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Adrian Mozzi
Venice Local (uncredited)
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Massi Furlan
Flight Attendant (uncredited)
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Michael Hennessy
Hotel Guest (uncredited)
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Meagan Holder
Pretty Tourist (uncredited)
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Patrick Holly
Partygoer (uncredited)
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Michael Iacono
Airport Kid Traveler (uncredited)
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Michal Kubal
Czech TV News Anchor (uncredited)
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Jessica VanOss
Student (uncredited)
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Géraldine Lamarre
Traffic Warden (uncredited)
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Jimena Larraguivel
Mexican Villager (uncredited)
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Rich Lawton
Journalist (uncredited)
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Kath Leroy
Czech Traditional Dancer (uncredited)
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Tony Mardon
Londoner (uncredited)
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Patrick Loh
Airport Passenger (uncredited)
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Marian Lorencik
New Czech Reveler (uncredited)
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Ketan Majmudar
Berlin Commuter (uncredited)
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Antonín Mašek
Bellboy (uncredited)
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Ben Mendelsohn
Talos (uncredited)
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Mike Ray
Passerby (uncredited)
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Anthony Molinari
Mob Guy (uncredited)
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Emily Ng
Italian Tourist (uncredited)
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Daniel Olson
Czech Guy (uncredited)
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Hiten Patel
British Station Staff (uncredited)
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Luigi Petrazzuolo
Gondolier (uncredited)
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Annie Pisapia
Traveler (uncredited)
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Jivan Xander Ramesh
Pedestrian (uncredited)
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Sofia Renee
High School Student (uncredited)
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Ray Rosario
TSA Agent (uncredited)
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Daniel Ryves
Dad Collecting Kids (uncredited)
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Maurice Sardison
Party Goer (uncredited)
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Emily Tebbutt
Venice Tourist (uncredited)
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Joakim Skarli
London Tourist (uncredited)
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Faith Tarby
Perfumed Lady (uncredited)
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Joe David Walters
Pawn Shop Owner (uncredited)
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Rocco Wu
Peter's Art Classmate (uncredited)
