암 치료를 위한 비밀 실험에 참여한 후, 강력한 힐링팩터 능력을 지닌 슈퍼히어로 데드풀로 거듭난 웨이드 윌슨은 여자친구 바네사와 더없이 행복한 시간을 보낸다. 그러나 행복도 잠시, 눈 앞에서 소중한 연인을 잃어버리고 삶의 의미를 상실하지만 자기 치유 능력 때문에 죽고 싶어도 죽지를 못한다. 밑바닥까지 내려간 데드풀은 더 나은 사람이 되기로 결심한다. 한편 미래에서 온 케이블은 러셀을 집요하게 쫓는다. 데드풀은 팀 엑스포스를 결성하고, 뭘 해도 운이 따르는 도미노가 엑스포스에 합류하는데...
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Ryan Reynolds
Wade Wilson / Deadpool / Juggernaut (voice) / Himself
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Josh Brolin
Nathan Summers / Cable
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Morena Baccarin
Vanessa Carlysle
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Julian Dennison
Russell Collins / Firefist
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Zazie Beetz
Neena Thurman / Domino
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T. J. Miller
Jack Hammer / Weasel
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Leslie Uggams
Blind Al
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Karan Soni
Dopinder
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Brianna Hildebrand
Ellie Phimister / Negasonic Teenage Warhead
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Jack Kesy
Black Tom Cassidy
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Eddie Marsan
Headmaster
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Shiori Kutsuna
Yukio / Pinkie Pie
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Stefan Kapičić
Piotr Rasputin / Colossus (voice)
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Randal Reeder
Buck
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Nikolai Witschl
Head Orderly Frye
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Thayr Harris
Sergei Valishnikov
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Rob Delaney
Peter
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Lewis Tan
Gaveedra-Seven / Shatterstar
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Bill Skarsgård
Axel Cluney / Zeitgeist
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Terry Crews
Jesse Aaronson / Bedlam
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Brad Pitt
Telford Porter / Vanisher
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Paul Wu
Hong Kong Boss
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Robert Maillet
Sluggo
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Alan Tudyk
Luke, Redneck #1
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Matt Damon
Redneck #2
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Michasha Armstrong
SWAT Captain (School)
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Joe Doserro
Bus Driver
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Hayley Sales
Cable's Wife
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Islie Hirvonen
Hope, Cable's Daughter
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Jagua Arneja
Tree Trimmer #1
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Gerry South
Tree Trimmer #2
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Mike Dopud
Prison Guard
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Luke Roessler
Cereal Kid
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Andy Canete
Neighbour #1
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Tanis Dolman
Neighbour #2
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Hunter Dillon
Branding Boy
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Sala Baker
Older Russell Collins / Firefist
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Sonia Sunger
News Reporter (Irene)
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Paul Wernick
News Cameraman
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Rhett Reese
News Helicopter Pilot
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Abiola Uthman
Chinook Pilot
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Tony Bailey
Black Tom Gang Member
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David Cook
Priest
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Alex Kliner
Park Bench Couple
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David Leitch
Ground Church Mutant
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Alicia Morton
Vocalist on 'Tomorrow' (singing voice)
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Fred Savage
Fred Savage
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Valencia Budijanto
Zoo Kid (uncredited)
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Lisa Bunting
Child Protection Worker (uncredited)
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Miles Ellis
Waving Prisoner (uncredited)
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Sean Gislingham
Sammy (uncredited)
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Lars Grant
Prison Guard 96S (uncredited)
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Sam Hargrave
DMC Guard (uncredited)
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Nicholas Hoult
Beast (uncredited)
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Simon MacIntyre
Business Passerby (uncredited)
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James McAvoy
Charles Xavier (uncredited)
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Evan Peters
Quicksilver (uncredited)
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Tye Sheridan
Cyclops (uncredited)
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Alexandra Shipp
Storm (uncredited)
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Kodi Smit-McPhee
Nightcrawler (uncredited)
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Andréa Vawda
News Anchor (uncredited)
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Scott Vickaryous
Thug (uncredited)
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Dan Zachary
Mutant Prisoner (uncredited)
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Hugh Jackman
Wolverine / Logan (archive footage)
