말하는 강아지 스쿠비는 멍뭉이 시절 만난 섀기와 친구들, 그리고 슈퍼히어로 블루 팔콘과 함께 지구에 대재앙을 불러올 무시무시한 음모를 꾸미는 악당 딕에 맞서게 되는데... 스쿠비와 함께 떠나는 미스터리 어드벤쳐! 겁쟁이 스쿠비는 슈퍼 히어로견으로 거듭날 수 있을까?
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Gina Rodriguez
Velma Dinkley (voice)
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Frank Welker
Scooby-Doo / Pterodactyl (voice)
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Ariana Greenblatt
Young Velma (voice)
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Christina Hendricks
Officer Jaffe (voice)
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Mckenna Grace
Young Daphne (voice)
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Mark Wahlberg
Blue Falcon (voice)
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Zac Efron
Fred Jones (voice)
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Amanda Seyfried
Daphne Blake (voice)
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Henry Winkler
Keith (voice)
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Will Forte
Shaggy Rogers (voice)
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Jason Isaacs
Dick Dastardly (voice)
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Iain Armitage
Young Shaggy (voice)
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Kiersey Clemons
Dee Dee Skyes (voice)
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Ken Jeong
Dynomutt, Dog Wonder (voice)
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Tracy Morgan
Captain Caveman (voice)
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Pierce Gagnon
Young Fred (voice)
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Simon Cowell
Himself (voice)
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John DiMaggio
Restaurant Owner (voice)
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Kevin Heffernan
Bike Cop Gary (voice)
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Maya Erskine
Judy Takamoto (voice)
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Billy West
Muttley (voice)
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Don Messick
Muttley (archive audio) (voice)
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Fred Tatasciore
Cerberus (voice)
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Justina Machado
Jamie Rivera (voice)
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Tony Cervone
Ghost / Mr. Rigby / Alice (voice)
